Confronting medicine’s flaws

Finding flaws: the limitations of compulsory licensing for improving access to medicines--an international comparison.

3 Serious Flaws in

Understanding the effect of a heuristic on the time complexity of the well-known A∗ search algorithm has been a subject of a large research body in AI. Among those researches is Korf et al.’s analysis (Korf & Reid, 1998; Korf et al., 2001; Korf, 2000a; Korf, 2000b), which concluded that the effect of a heuristic is to reduce the effective depth rather than effective branching factor. Since this...

Design flaws in EuroSCORE II.

We recently read with great interest and anticipation the development of the EuroSCORE II. However, we have methodological concerns relating to how EuroSCORE II was developed and evaluated [1] and subsequent comments made in an editorial by the authors responding to recent criticisms [2]. We focus on the strategy and study design used to derive and evaluate the model. The authors randomly split...

Flaws in the Efficiency Gap

Gerrymandering is returning to the Supreme Court. For the first time in three decades, a federal court invalidated redistricting legislation on the grounds that it constituted a partisan gerrymander in violation of the Fourteenth Amendment. That court relied, in part, on a new tool—the efficiency gap—which some have touted as the means to “end gerrymandering once and for all.” We evaluate this ...

Confronting Antimicrobial Resistance

88 AMR CONTROL 2015 T he story of anti-tuberculosis chemotherapy is a miniature of the history of anti-infective chemotherapy. In the first half of the twentieth century the problem of tuberculosis appeared insolvable due to the lipid-rich cell wall that was believed to make chemotherapy impossible (1). This gloomy view seemed to be confirmed when the first antibiotics developed, sulfonamides a...